Children and adults can develop a serious disease, called pulmonary hypertension (PH) in the setting of congenital heart disease, lung disease, and mutations. The goal of our lab is to understand the mechanisms driving pulmonary vascular disease associated with PH and establish novel therapies for treatment. To do this, our laboratory studies the normal development of the heart, lung, and pulmonary vasculature to identify signaling mechanisms promoting vascular development, regeneration, and homeostasis. We apply novel ex vivo modeling, advanced whole organ imaging, single-cell and population RNA sequencing, CRISPR-Cas9 gene editing and gene therapy, transgenic mouse modeling, and the use of human tissue to unravel mechanisms of cardiopulmonary development.