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06-09-22 Frank Lab Portraits (Sukhmani Kaur)033-7_edited.jpg

Our Science


Children and adults can develop a serious disease, called pulmonary hypertension (PH) in the setting of congenital heart disease, lung disease, and mutations. The goal of our lab is to understand the mechanisms driving pulmonary vascular disease associated with PH and establish novel therapies for treatment. To do this, our laboratory studies the normal development of the heart, lung, and pulmonary vasculature to identify signaling mechanisms promoting vascular development, regeneration, and homeostasis. We apply novel ex vivo modeling, advanced whole organ imaging, single-cell and population RNA sequencing, CRISPR-Cas9 gene editing and gene therapy, transgenic mouse modeling, and the use of human tissue to unravel mechanisms of cardiopulmonary development.

To accomplish this, our lab is focused on three areas of research: 

Development and Disease of the Pulmonary Vasculature

Defining early ontogeny from cardiopulmonary progenitor cells

Assessing morphogenesis and growth of the pulmonary arterial tree

Developing novel models of lineage tracing in pulmonary vascular disease

Lung Development 

Elucidating the role of BRD4 in lung development, disease, and regeneration

Determining converging signaling pathways in WNT responsive alveolar stem cells

Rare Lung Disease

Maintaining one of the largest pediatric lung biorepositories to study rare lung disease

Uncovering therapeutic targets in congenital pulmonary airway malformation (CPAMs)

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